Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis

BACKGROUND & AIMS: Aramchol is a fatty acid-bile acid conjugate that reduces liver fat content and is being evaluated in a phase III clinical trial for non-alcoholic steatohepatitis (NASH). Aramchol attenuates NASH in mouse models and decreases steatosis by downregulating the fatty acid syntheti...

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Pubblicato in:JHEP Rep
Autori principali: Bhattacharya, Dipankar, Basta, Brittany, Mato, Jose M., Craig, Amanda, Fernández-Ramos, David, Lopitz-Otsoa, Fernando, Tsvirkun, Darya, Hayardeny, Liat, Chandar, Vasuretha, Schwartz, Robert E., Villanueva, Augusto, Friedman, Scott L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8189934/
https://ncbi.nlm.nih.gov/pubmed/34151243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhepr.2021.100237
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