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Naive stem cell blastocyst model captures human embryo lineage segregation

Human naive pluripotent cells can differentiate into extraembryonic trophectoderm and hypoblast. Here we describe a human embryo model (blastoid) generated by self-organization. Brief induction of trophectoderm leads to formation of blastocyst-like structures within 3 days. Blastoids are composed of...

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Détails bibliographiques
Publié dans:Cell Stem Cell
Auteurs principaux: Yanagida, Ayaka, Spindlow, Daniel, Nichols, Jennifer, Dattani, Anish, Smith, Austin, Guo, Ge
Format: Artigo
Langue:Inglês
Publié: Cell Press 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8189436/
https://ncbi.nlm.nih.gov/pubmed/33957081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2021.04.031
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