Blocking CCN2 Preferentially Inhibits Osteoclastogenesis Induced by Repetitive High Force Bone Loading

PURPOSE/AIM. We recently found that blocking CCN2 signaling using a monoclonal antibody (FG-3019) may be a novel therapeutic strategy for reducing overuse-induced tissue fibrosis. Since CCN2 plays roles in osteoclastogenesis, and persistent performance of a high repetition high force (HRHF) lever pu...

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Publicado en:Connect Tissue Res
Autores principales: Barbe, Mary F, Amin, Mamta, Gingery, Anne, Lambi, Alex G, Popoff, Steven N
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8189320/
https://ncbi.nlm.nih.gov/pubmed/32683988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/03008207.2020.1788546
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