Cardiac Mesenchymal Cells Cultured at Physiologic Oxygen Tension Have Superior Therapeutic Efficacy in Heart Failure Caused by Myocardial Infarction

Stem/progenitor cells are usually cultured at atmospheric O(2) tension (21%); however, since physiologic O(2) tension in the heart is ∼5%, using 21% O(2) may cause oxidative stress and toxicity. Cardiac mesenchymal cells (CMCs), a newly discovered and promising type of progenitor cells, are effectiv...

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Udgivet i:Front Cell Dev Biol
Main Authors: Bolli, Robi A. R., Arshia, Asma, Hassan, Syed A., Dasari, Chandrashekhar, Nong, Yibing, Guo, Yiru, Tomlin, Alex A., Li, Qianhong
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8189180/
https://ncbi.nlm.nih.gov/pubmed/34124043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.662415
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