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Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is the most common type of dementia characterized by the abnormal accumulation of amyloid-β (Aβ) in the brain. Aβ misfolding is associated with neuroinflammation and synaptic dysfunction, leading to learning and memory deficits. Therefore, Aβ production and aggregation have...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Park, Sohui, Kim, Hye Yun, Oh, Hyun-A, Shin, Jisu, Park, In Wook, Yoon, Soljee, Woo, Dong Ho, Kim, YoungSoo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187640/
https://ncbi.nlm.nih.gov/pubmed/34103615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91563-y
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