Increasing the Ascomycin Yield by Relieving the Inhibition of Acetyl/Propionyl-CoA Carboxylase by the Signal Transduction Protein GlnB

Ascomycin (FK520) is a multifunctional antibiotic produced by Streptomyces hygroscopicus var. ascomyceticus. In this study, we demonstrated that the inactivation of GlnB, a signal transduction protein belonging to the PII family, can increase the production of ascomycin by strengthening the supply o...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Wang, Pan, Wang, Xin, Yin, Ying, He, Mingliang, Tan, Wei, Gao, Wenting, Wen, Jianping
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187598/
https://ncbi.nlm.nih.gov/pubmed/34122395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2021.684193
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