Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40

Immunologically-cold tumors including glioblastoma (GBM) are refractory to checkpoint blockade therapy, largely due to extensive infiltration of immunosuppressive macrophages (Mϕs). Consistent with a pro-tumor role of IL-6 in alternative Mϕs polarization, we here show that targeting IL-6 by genetic...

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Udgivet i:Nat Commun
Main Authors: Yang, Fan, He, Zhenqiang, Duan, Hao, Zhang, Duo, Li, Juehui, Yang, Huijuan, Dorsey, Jay F., Zou, Wei, Nabavizadeh, S. Ali, Bagley, Stephen J., Abdullah, Kalil, Brem, Steven, Zhang, Lin, Xu, Xiaowei, Byrne, Katelyn T., Vonderheide, Robert H., Gong, Yanqing, Fan, Yi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187342/
https://ncbi.nlm.nih.gov/pubmed/34103524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23832-3
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