The push-to-open mechanism of the tethered mechanosensitive ion channel NompC

NompC is a mechanosensitive ion channel responsible for the sensation of touch and balance in Drosophila melanogaster. Based on a resolved cryo-EM structure, we performed all-atom molecular dynamics simulations and electrophysiological experiments to study the atomistic details of NompC gating. Our...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Wang, Yang, Guo, Yifeng, Li, Guanluan, Liu, Chunhong, Wang, Lei, Zhang, Aihua, Yan, Zhiqiang, Song, Chen
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2021
Matèries:
Computational and Systems Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186909/
https://ncbi.nlm.nih.gov/pubmed/34101577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58388
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