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Analysis of Variability in the Rabbit Skin Irritation Assay

The in vivo rabbit test is the benchmark against which new approach methodologies for skin irritation are usually compared. No alternative method offers a complete replacement of animal use for this endpoint for all regulatory applications. Variability in the animal reference data may be a limiting...

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Detalhes bibliográficos
Publicado no:Regul Toxicol Pharmacol
Main Authors: Rooney, John P., Choksi, Neepa Y., Ceger, Patricia, Daniel, Amber B., Truax, James, Allen, David, Kleinstreuer, Nicole
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186434/
https://ncbi.nlm.nih.gov/pubmed/33757807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yrtph.2021.104920
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