Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-γ

Peripheral nerve injury can cause debilitating disease and immune cell–mediated destruction of the affected nerve. While the focus has been on the nerve-regenerative response, the effect of loss of innervation on lymph node function is unclear. Here, we show that the popliteal lymph node (popLN) rec...

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Udgivet i:J Exp Med
Main Authors: Chen, Chien-Sin, Weber, Jasmin, Holtkamp, Stephan Jonas, Ince, Louise Madeleine, de Juan, Alba, Wang, Chen, Lutes, Lydia, Barnoud, Coline, Kizil, Burak, Hergenhan, Sophia Martina, Salvermoser, Johanna, Lasch, Manuel, Deindl, Elisabeth, Schraml, Barbara, Baumjohann, Dirk, Scheiermann, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185988/
https://ncbi.nlm.nih.gov/pubmed/34086056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202377
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