Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells

Human pluripotent stem cell (hPSC)-derived pancreatic β cells are an attractive cell source for treating diabetes. However, current derivation methods remain inefficient, heterogeneous, and cell line dependent. To address these issues, we first devised a strategy to efficiently cluster hPSC-derived...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Liu, Haisong, Li, Ronghui, Liao, Hsin-Kai, Min, Zheying, Wang, Chao, Yu, Yang, Shi, Lei, Dan, Jiameng, Hayek, Alberto, Martinez Martinez, Llanos, Nuñez Delicado, Estrella, Izpisua Belmonte, Juan Carlos
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184986/
https://ncbi.nlm.nih.gov/pubmed/34099664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23525-x
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