Ibrutinib does not prevent kidney fibrosis following acute and chronic injury

Recent studies suggested that ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, developed for the treatment of chronic lymphocytic leukemia, may prevent NLRP3 inflammasome activation in macrophages, IL-1β secretion and subsequent development of inflammation and organ fibrosis. The role of NLRP3 h...

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Publicat a:Sci Rep
Autors principals: Belliere, Julie, Casemayou, Audrey, Colliou, Eloïse, El Hachem, Hélène, Kounde, Clément, Piedrafita, Alexis, Feuillet, Guylène, Schanstra, Joost P., Faguer, Stanislas
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184891/
https://ncbi.nlm.nih.gov/pubmed/34099830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91491-x
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