Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here, we use Diversity Outbred (DO) mice to directly addr...

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Publicado en:Nat Commun
Autores principales: Al-Barghouthi, Basel M., Mesner, Larry D., Calabrese, Gina M., Brooks, Daniel, Tommasini, Steven M., Bouxsein, Mary L., Horowitz, Mark C., Rosen, Clifford J., Nguyen, Kevin, Haddox, Samuel, Farber, Emily A., Onengut-Gumuscu, Suna, Pomp, Daniel, Farber, Charles R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184749/
https://ncbi.nlm.nih.gov/pubmed/34099702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23649-0
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