β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity

Obesity is the key driver of peripheral insulin resistance, one of the key features of type 2 diabetes (T2D). In insulin-resistant individuals, the expansion of beta-cell mass is able to delay or even prevent the onset of overt T2D. Here, we report that beta-arrestin-1 (barr1), an intracellular prot...

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Vydáno v:Nat Commun
Hlavní autoři: Barella, Luiz F., Rossi, Mario, Pydi, Sai P., Meister, Jaroslawna, Jain, Shanu, Cui, Yinghong, Gavrilova, Oksana, Fulgenzi, Gianluca, Tessarollo, Lino, Wess, Jürgen
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184739/
https://ncbi.nlm.nih.gov/pubmed/34099679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23656-1
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