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Pore mutation N617D in the skeletal muscle DHPR blocks Ca(2+) influx due to atypical high-affinity Ca(2+) binding
Skeletal muscle excitation-contraction (EC) coupling roots in Ca(2+)-influx-independent inter-channel signaling between the sarcolemmal dihydropyridine receptor (DHPR) and the ryanodine receptor (RyR1) in the sarcoplasmic reticulum. Although DHPR Ca(2+) influx is irrelevant for EC coupling, its puta...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8184209/ https://ncbi.nlm.nih.gov/pubmed/34061024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.63435 |
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