Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor-binding domain (RBD) and the S1 subunit (S1) of the spike protein of SARS-CoV-2 to epithelial cells. In Vero E6 cells, hypoxia reduces the protein levels of ACE2 and n...

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Опубликовано в: :Emerg Microbes Infect
Главные авторы: Prieto-Fernández, Endika, Egia-Mendikute, Leire, Vila-Vecilla, Laura, Bosch, Alexandre, Barreira-Manrique, Adrián, Lee, So Young, García-del Río, Ana, Antoñana-Vildosola, Asier, Jiménez-Lasheras, Borja, Moreno-Cugnon, Leire, Jiménez-Barbero, Jesús, Berra, Edurne, Ereño-Orbea, June, Palazon, Asis
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2021
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183554/
https://ncbi.nlm.nih.gov/pubmed/34013835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/22221751.2021.1932607
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