CMTM6-Deficient Monocytes in ANCA-Associated Vasculitis Fail to Present the Immune Checkpoint PD-L1

OBJECTIVES: ANCA-associated vasculitides (AAV) affect small- and medium-sized blood vessels. In active disease, vessel wall infiltrates are mainly composed of monocytes and macrophages. Immune checkpoint molecules are crucial for the maintenance of self-tolerance and the prevention of autoimmune dis...

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Publicat a:Front Immunol
Autors principals: Zeisbrich, Markus, Chevalier, Nina, Sehnert, Bettina, Rizzi, Marta, Venhoff, Nils, Thiel, Jens, Voll, Reinhard E.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183471/
https://ncbi.nlm.nih.gov/pubmed/34108971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.673912
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