Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma

BACKGROUND: Glioblastoma (GBM) is refractory to immune checkpoint inhibitor (ICI) therapy. We sought to determine to what extent this immune evasion is due to intrinsic properties of the tumor cells versus the specialized immune context of the brain, and if it can be reversed. METHODS: We used CyTOF...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Simonds, Erin F, Lu, Edbert D, Badillo, Oscar, Karimi, Shokoufeh, Liu, Eric V, Tamaki, Whitney, Rancan, Chiara, Downey, Kira M, Stultz, Jacob, Sinha, Meenal, McHenry, Lauren K, Nasholm, Nicole M, Chuntova, Pavlina, Sundström, Anders, Genoud, Vassilis, Shahani, Shilpa A, Wang, Leo D, Brown, Christine E, Walker, Paul R, Swartling, Fredrik J, Fong, Lawrence, Okada, Hideho, Weiss, William A, Hellström, Mats
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2021
Témata:
Basic Tumor Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183210/
https://ncbi.nlm.nih.gov/pubmed/34083417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-002181
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