Baseline and early functional immune response is associated with subsequent clinical outcomes of PD-1 inhibition therapy in metastatic melanoma patients

BACKGROUND: Despite significant progress with antiprogrammed cell death protein 1 (PD-1) therapy, a substantial fraction of metastatic melanoma patients show upfront therapy resistance. Biomarkers for outcome are missing and the association of baseline immune function and clinical outcome remains to...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Gérard, Alexandre, Doyen, Jerome, Cremoni, Marion, Bailly, Laurent, Zorzi, Kevin, Ruetsch-Chelli, Caroline, Brglez, Vesna, Picard-Gauci, Alexandra, Troin, Laura, Esnault, Vincent L.M., Passeron, Thierry, Montaudié, Henri, Seitz-Polski, Barbara
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2021
Schlagworte:
Clinical/Translational Cancer Immunotherapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183201/
https://ncbi.nlm.nih.gov/pubmed/34088741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002512
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