Combined targeting of PARG and Wee1 causes decreased cell survival and DNA damage in an S-phase dependent manner.

The DNA damage response (DDR) pathway sets the stage for tumorigenesis and provides both an opportunity for drug efficacy and resistance. Therapeutic approaches to target the DDR pathway include aiming to increase the efficacy of cytotoxic chemotherapies and synergistic drug strategies to enhance DN...

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Vydáno v:Mol Cancer Res
Hlavní autoři: Agostini, Lebaron C., Jain, Aditi, Shupp, Alison, Nevler, Avinoam, McCarthy, Grace, Bussard, Karen M., Yeo, Charles J, Brody, Jonathan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8182744/
https://ncbi.nlm.nih.gov/pubmed/33257507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0708
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