An SNX10-dependent mechanism downregulates fusion between mature osteoclasts

Homozygosity for the R51Q mutation in sorting nexin 10 (SNX10) inactivates osteoclasts (OCLs) and induces autosomal recessive osteopetrosis in humans and in mice. We show here that the fusion of wild-type murine monocytes to form OCLs is highly regulated, and that its extent is limited by blocking f...

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Vydáno v:J Cell Sci
Hlavní autoři: Barnea-Zohar, Maayan, Winograd-Katz, Sabina E., Shalev, Moran, Arman, Esther, Reuven, Nina, Roth, Lee, Golani, Ofra, Stein, Merle, Thalji, Fadi, Kanaan, Moien, Tuckermann, Jan, Geiger, Benjamin, Elson, Ari
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8182410/
https://ncbi.nlm.nih.gov/pubmed/33975343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.254979
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