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Streamlined construction of peptide macrocycles via palladium-catalyzed intramolecular S-arylation in solution and on DNA
A highly efficient and versatile method for construction of peptide macrocycles via palladium-catalyzed intramolecular S-arylation of alkyl and aryl thiols with aryl iodides under mild conditions is developed. The method exhibits a broad substrate scope for thiols, aryl iodides and amino acid units....
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| Udgivet i: | Chem Sci |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Royal Society of Chemistry
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8179660/ https://ncbi.nlm.nih.gov/pubmed/34168804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc00789k |
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