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A novel catalytic heme cofactor in SfmD with a single thioether bond and a bis-His ligand set revealed by a de novo crystal structural and spectroscopic study
SfmD is a heme-dependent enzyme in the biosynthetic pathway of saframycin A. Here, we present a 1.78 Å resolution de novo crystal structure of SfmD, which unveils a novel heme cofactor attached to the protein with an unusual Hx(n)HxxxC motif (n ∼ 38). This heme cofactor is unique in two respects. It...
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| Veröffentlicht in: | Chem Sci |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Royal Society of Chemistry
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8179489/ https://ncbi.nlm.nih.gov/pubmed/34163669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc06369j |
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