DLL1 orchestrates CD8(+) T cells to induce long-term vascular normalization and tumor regression

The immunosuppressive and hypoxic tumor microenvironment (TME) remains a major obstacle to impede cancer immunotherapy. Here, we showed that elevated levels of Delta-like 1 (DLL1) in the breast and lung TME induced long-term tumor vascular normalization to alleviate tumor hypoxia and promoted the ac...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Zhang, Naidong, Yin, Rongping, Zhou, Pei, Liu, Xiaomei, Fan, Peng, Qian, Long, Dong, Li, Zhang, Chenglin, Zheng, Xichen, Deng, Shengming, Kuai, Jiajie, Liu, Zhenhua, Jiang, Wen, Wang, Xiaohua, Wu, Depei, Huang, Yuhui
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179177/
https://ncbi.nlm.nih.gov/pubmed/34035167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020057118
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