Trametinib therapy for children with neurofibromatosis type 1 and life‐threatening plexiform neurofibroma or treatment‐refractory low‐grade glioma

PURPOSE: To describe a series of children with extensive PNF or treatment refractory PLGG treated on a compassionate basis with trametinib. METHODS: We report on six patients with NF‐1 treated with trametinib on a compassionate basis at British Columbia Children's Hospital since 2017. Data were...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Med
Main Authors: Ronsley, Rebecca, Hounjet, Celine D., Cheng, Sylvia, Rassekh, Shahrad Rod, Duncan, Walter J., Dunham, Christopher, Gardiner, Jane, Ghag, Arvindera, Ludemann, Jeffrey P., Wensley, David, Rehmus, Wingfield, Sargent, Michael A., Hukin, Juliette
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2021
Teme:
Clinical Cancer Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178485/
https://ncbi.nlm.nih.gov/pubmed/33939292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3910
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