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A critical role for Th17 cell-derived TGF-β1 in regulating the stability and pathogenicity of autoimmune Th17 cells

Pathogenic conversion of Th17 cells into multifunctional helper T cells or Th1 cells contributes to the pathogenesis of autoimmune diseases; however, the mechanism regulating the plasticity of Th17 cells remains unclear. Here, we found that Th17 cells expressed latent TGF-β1 in a manner dependent on...

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Publicat a:Exp Mol Med
Autors principals: Choi, Garam, Park, Young-Jun, Cho, Minkyoung, Moon, Heesu, Kim, Daehong, Kang, Chang-Yuil, Chung, Yeonseok, Kim, Byung-Seok
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178381/
https://ncbi.nlm.nih.gov/pubmed/34050263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-021-00632-9
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