Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells

The imipramine ONC201 has antiproliferative effects in several cancer cell types and activates integrated stress response pathway associated with the induction of Damage Inducible Transcript 3 (DDIT3, also known as C/EBP homologous protein or CHOP). We investigated the signaling pathways through whi...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Al Madhoun, Ashraf, Haddad, Dania, Al Tarrah, Mustafa, Jacob, Sindhu, Al-Ali, Waleed, Nizam, Rasheeba, Miranda, Lavina, Al-Rashed, Fatema, Sindhu, Sardar, Ahmad, Rasheed, Bitar, Milad S., Al-Mulla, Fahd
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178367/
https://ncbi.nlm.nih.gov/pubmed/34088951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91092-8
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