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Amino acid-based H(2)S Donors: N-Thiocarboxyanhydrides that release H(2)S with innocuous byproducts

A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H(2)S-release kinetics is reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing don...

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Bibliografiske detaljer
Udgivet i:Chem Commun (Camb)
Main Authors: Kaur, Kuljeet, Enders, Patrick, Zhu, Jackie, Bratton, Abigail F., Powell, Chadwick R., Kashfi, Khosrow, Matson, John B.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178226/
https://ncbi.nlm.nih.gov/pubmed/33956024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1cc01309b
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