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Amino acid-based H(2)S Donors: N-Thiocarboxyanhydrides that release H(2)S with innocuous byproducts

A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H(2)S-release kinetics is reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing don...

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Détails bibliographiques
Publié dans:Chem Commun (Camb)
Auteurs principaux: Kaur, Kuljeet, Enders, Patrick, Zhu, Jackie, Bratton, Abigail F., Powell, Chadwick R., Kashfi, Khosrow, Matson, John B.
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178226/
https://ncbi.nlm.nih.gov/pubmed/33956024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1cc01309b
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