Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding

The Parkin Co-Regulated Gene (PACRG) binds at the inner junction between doublet microtubules of the axoneme, a structure found in flagella and cilia. PACRG binds to the adaptor protein meiosis expressed gene 1 (MEIG1), but how they bind to microtubules is unknown. Here, we report the crystal struct...

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Published in:Structure
Main Authors: Khan, Nimra, Pelletier, Dylan, McAlear, Thomas S., Croteau, Nathalie, Veyron, Simon, Bayne, Andrew N., Black, Corbin, Ichikawa, Muneyoshi, Khalifa, Ahmad Abdelzaher Zaki, Chaaban, Sami, Kurinov, Igor, Brouhard, Gary, Bechstedt, Susanne, Bui, Khanh Huy, Trempe, Jean-François
Format: Artigo
Language:Inglês
Published: 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178172/
https://ncbi.nlm.nih.gov/pubmed/33529594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2021.01.001
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