Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice

INTRODUCTION: Mast cell (MC) activation could establish a positive feedback loop that perpetuates inflammation and maintains pain. Stabilizing MCs with ketotifen fumarate (KF) may disrupt this loop and relieve pain. OBJECTIVE: We aimed to test the effect of treatment with KF in pain assays in mice a...

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Veröffentlicht in:Pain Rep
Hauptverfasser: Meloto, Carolina B., Ingelmo, Pablo, Perez, Eduardo Vega, Pitt, Rebecca, González Cárdenas, Víctor Hugo, Mohamed, Nada, Sotocinal, Susana G., Bourassa, Valerie, Lima, Lucas Vasconcelos, Ribeiro-da-Silva, Alfredo, Mogil, Jeffrey S., Diatchenko, Luda
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wolters Kluwer 2021
Schlagworte:
Basic Science
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177879/
https://ncbi.nlm.nih.gov/pubmed/34104835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PR9.0000000000000902
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