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IL15 Infusion of Cancer Patients Expands the Subpopulation of Cytotoxic CD56(bright) NK Cells and Increases NK-Cell Cytokine Release Capabilities

The cytokine IL15 is required for survival and activation of natural killer (NK) cells as well as expansion of NK-cell populations. Here, we compare the effects of continuous IL15 infusions on NK-cell subpopulations in cancer patients. Infusions affected the CD56(bright) NK-cell subpopulation in tha...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Dubois, Sigrid, Conlon, Kevin C., Müller, Jürgen R., Hsu-Albert, Jennifer, Beltran, Nancy, Bryant, Bonita R., Waldmann, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177006/
https://ncbi.nlm.nih.gov/pubmed/28842470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0279
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