Mechanism‐based treatment of cancer with immune checkpoint inhibitor therapies

Immune checkpoints are cell surface molecules that initiate regulatory pathways which have powerful control of CD8(+) cytolytic T cell activity. Antagonistic and agonistic antibodies engaging these molecules have demonstrated profound impact on immune activation and have entered clinical use for the...

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Bibliographic Details
Published in:Br J Clin Pharmacol
Main Authors: Abdou, Yara, Pandey, Manu, Sarma, Maithreyi, Shah, Shrunjal, Baron, Jeffrey, Ernstoff, Marc S.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Reviews ‐ Themed Section
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176998/
https://ncbi.nlm.nih.gov/pubmed/32323342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14316
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