Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease

The pathophysiology of sickle cell disease (SCD) is driven by chronic inflammation fueled by damage associated molecular patterns (DAMPs). We show that elevated cell-free DNA (cfDNA) in patients with SCD is not just a prognostic biomarker, it also contributes to the pathological inflammation. Within...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Blood
Κύριοι συγγραφείς: Tumburu, Laxminath, Ghosh-Choudhary, Shohini, Seifuddin, Fayaz T., Barbu, Emilia A., Yang, Simon, Ahmad, Maliha M., Wilkins, Lauren H. W., Tunc, Ilker, Sivakumar, Ishwarya, Nichols, James S., Dagur, Pradeep K., Yang, Shutong, Almeida, Luis E. F., Quezado, Zenaide M. N., Combs, Christian A., Lindberg, Eric, Bleck, Christopher K. E., Zhu, Jun, Shet, Arun S., Chung, Jay H., Pirooznia, Mehdi, Thein, Swee Lay
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society of Hematology 2021
Θέματα:
Red Cells, Iron, and Erythropoiesis
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176765/
https://ncbi.nlm.nih.gov/pubmed/33661274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009063
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