Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist

Dopamine D1 receptor (D1R) is an important drug target implicated in many psychiatric and neurological disorders. Selective agonism of D1R are sought to be the therapeutic strategy for these disorders. Most selective D1R agonists share a dopamine-like catechol moiety in their molecular structure, an...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Sun, Bingfa, Feng, Dan, Chu, Matthew Ling-Hon, Fish, Inbar, Lovera, Silvia, Sands, Zara A., Kelm, Sebastian, Valade, Anne, Wood, Martyn, Ceska, Tom, Kobilka, Tong Sun, Lebon, Florence, Kobilka, Brian K.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175458/
https://ncbi.nlm.nih.gov/pubmed/34083522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23519-9
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