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Acute myeloid leukemia with IDH1 and IDH2 mutations: 2021 treatment algorithm

Acute myeloid leukemia is a genetically heterogeneous hematologic malignancy; approximately 20% of AML harbors a mutation in the isocitrate dehydrogenase (IDH) genes, IDH1 or IDH2. These recurrent mutations in key metabolic enzymes lead to the production of the oncometabolite 2-hydroxyglutarate, whi...

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Dades bibliogràfiques
Publicat a:Blood Cancer J
Autors principals: Issa, Ghayas C., DiNardo, Courtney D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175383/
https://ncbi.nlm.nih.gov/pubmed/34083508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-021-00497-1
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