Polyvinyl Alcohol/Chitosan Single-Layered and Polyvinyl Alcohol/Chitosan/Eudragit RL100 Multi-layered Electrospun Nanofibers as an Ocular Matrix for the Controlled Release of Ofloxacin: an In Vitro and In Vivo Evaluation

A novel nanofiber insert was prepared with a modified electrospinning method to enhance the ocular residence time of ofloxacin (OFX) and to provide a sustained release pattern by covering hydrophilic polymers, chitosan/polyvinyl alcohol (CS/PVA) nanofibers, with a hydrophobic polymer, Eudragit RL100...

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Dettagli Bibliografici
Pubblicato in:AAPS PharmSciTech
Autori principali: Mirzaeei, Shahla, Taghe, Shiva, Asare-Addo, Kofi, Nokhodchi, Ali
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175245/
https://ncbi.nlm.nih.gov/pubmed/34085150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-021-02051-5
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