Exosomal MATN3 of Urine-Derived Stem Cells Ameliorates Intervertebral Disc Degeneration by Antisenescence Effects and Promotes NPC Proliferation and ECM Synthesis by Activating TGF-β

OBJECTIVE: Low back pain (LBP) is one of the top three causes of disability in developed countries, and intervertebral disc degeneration (IDD) is a major contributor to LBP. In the process of IDD, there is a gradual decrease in nucleus pulposus cells (NPCs) and extracellular matrix (ECM). Exosomes a...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oxid Med Cell Longev
Auteurs principaux: Guo, Zhu, Su, WeiLiang, Zhou, RongYao, Zhang, GuoQing, Yang, Shuai, Wu, XiaoLin, Qiu, ChenSheng, Cong, WenBin, Shen, Nana, Guo, JianWei, Liu, Chang, Yang, Shang-You, Xing, DongMing, Wang, Yan, Chen, BoHua, Xiang, HongFei
Format: Artigo
Langue:Inglês
Publié: Hindawi 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175180/
https://ncbi.nlm.nih.gov/pubmed/34136064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/5542241
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