Unique Human and Mouse β-Cell Senescence-Associated Secretory Phenotype (SASP) Reveal Conserved Signaling Pathways and Heterogeneous Factors

The aging of pancreatic β-cells may undermine their ability to compensate for insulin resistance, leading to the development of type 2 diabetes (T2D). Aging β-cells acquire markers of cellular senescence and develop a senescence-associated secretory phenotype (SASP) that can lead to senescence and d...

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Опубликовано в: :Diabetes
Главные авторы: Midha, Ayush, Pan, Hui, Abarca, Cristian, Andle, Joshua, Carapeto, Priscila, Bonner-Weir, Susan, Aguayo-Mazzucato, Cristina
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2021
Предметы:
Islet Studies
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8173799/
https://ncbi.nlm.nih.gov/pubmed/33674410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0553
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