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JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells

SARS-CoV-2 infection of human airway epithelium activates genetic programs leading to progressive hyperinflammation in COVID-19 patients. Here, we report on transcriptomes activated in primary airway cells by interferons and their suppression by Janus kinase (JAK) inhibitors. Deciphering the regulat...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Commun Biol
Päätekijät: Lee, Hye Kyung, Jung, Olive, Hennighausen, Lothar
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8172581/
https://ncbi.nlm.nih.gov/pubmed/34079039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02167-1
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