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PIKE-R2P: Protein–protein interaction network-based knowledge embedding with graph neural network for single-cell RNA to protein prediction

BACKGROUND: Recent advances in simultaneous measurement of RNA and protein abundances at single-cell level provide a unique opportunity to predict protein abundance from scRNA-seq data using machine learning models. However, existing machine learning methods have not considered relationship among th...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Dai, Xinnan, Xu, Fan, Wang, Shike, Mundra, Piyushkumar A., Zheng, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170782/
https://ncbi.nlm.nih.gov/pubmed/34078261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-021-04022-w
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