Yap1-2 Isoform Is the Primary Mediator in TGF-β1 Induced EMT in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive human malignancy and intrinsically resistant to conventional therapies. YAP1, as a key downstream effector of the Hippo pathway, plays an important role in tumorigenesis including PDAC. Alternative mRNA splicing of YAP1 results in at lea...

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Bibliographische Detailangaben
Veröffentlicht in:Front Oncol
Hauptverfasser: Gao, Chao, Quan, Mei-Yu, Chen, Qian-Jie, Yang, Ruo, Wu, Yuanyuan, Liu, Jia-Yu, Lin, Zhong-Yuan, Li, Xue, Cai, Jue-Ting, Jiang, Tian-Fang, Xu, Le, Mossahebi-Mohammadi, Majid, Guo, Qiang, Zhang, Jin-San
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170464/
https://ncbi.nlm.nih.gov/pubmed/34094936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.649290
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