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Dynamic patterns of DNA methylation in the normal prostate epithelial differentiation program are targets of aberrant methylation in prostate cancer

Understanding the epigenetic control of normal differentiation programs might yield principal information about critical regulatory states that are disturbed in cancer. We utilized the established non-malignant HPr1-AR prostate epithelial cell model that upon androgen exposure commits to a luminal c...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Long, Mark D., Dhiman, Vineet K., Affronti, Hayley C., Hu, Qiang, Liu, Song, Smiraglia, Dominic J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169877/
https://ncbi.nlm.nih.gov/pubmed/34075163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91037-1
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