In vivo self-assembled small RNAs as a new generation of RNAi therapeutics

RNAi therapy has undergone two stages of development, direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands; both have not solved the problem of efficient in vivo siRNA delivery. Here, we present a proof-of-principle strategy that reprogrammes host liver wi...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Fu, Zheng, Zhang, Xiang, Zhou, Xinyan, Ur-Rehman, Uzair, Yu, Mengchao, Liang, Hongwei, Guo, Hongyuan, Guo, Xu, Kong, Yan, Su, Yuanyuan, Ye, Yangyang, Hu, Xiuting, Cheng, Wei, Wu, Jinrong, Wang, Yanbo, Gu, Yayun, Lu, Sheng-feng, Wu, Dianqing, Zen, Ke, Li, Jing, Yan, Chao, Zhang, Chen-Yu, Chen, Xi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169669/
https://ncbi.nlm.nih.gov/pubmed/33782530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-021-00491-z
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