Single Cell RNA-Sequencing Uncovers Paracrine Functions of the Epicardial-Derived Cells in Arrhythmogenic Cardiomyopathy

BACKGROUND: Arrhythmogenic cardiomyopathy (ACM) manifests with sudden death, arrhythmias, heart failure, apoptosis, and myocardial fibro-adipogenesis. The phenotype typically starts at the epicardium and advances transmurally. Mutations in genes encoding desmosome proteins, including DSP (desmoplaki...

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Vydáno v:Circulation
Hlavní autoři: Yuan, Ping, Cheedipudi, Sirisha M, Rouhi, Leila, Fan, Siyang, Simon, Lukas, Zhao, Zhongming, Hong, Kui, Gurha, Priyatansh, Marian, Ali J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169643/
https://ncbi.nlm.nih.gov/pubmed/33726497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.120.052928
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