Potentiation of (α4)2(β2)3, but not (α4)3(β2)2, Nicotinic Acetylcholine Receptors Reduces Nicotine Self-Administration and Withdrawal Symptoms

The low sensitivity (α4)3(β2)2 (LS) and high sensitivity (α4)2(β2)3 (HS) nAChR isoforms may contribute to a variety of brain functions, pathophysiological processes, and pharmacological effects associated with nicotine use. In this study, we examined the contributions of the LS and HS α4β2 nAChR iso...

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Détails bibliographiques
Publié dans:Neuropharmacology
Auteurs principaux: Hamouda, Ayman K., Bautista, Malia R., Akinola, Lois S., Alkhlaif, Yasmin, Jackson, Asti, Carper, Moriah, Toma, Wisam B., Garai, Sumanta, Chen, Yen-Chu, Thakur, Ganesh A., Fowler, Christie D., Damaj, M. Imad
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169606/
https://ncbi.nlm.nih.gov/pubmed/33878302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2021.108568
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