Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs

Several genome-wide CRISPR knockout screens have been conducted to identify host factors regulating SARS-CoV-2 replication, but the models used have often relied on overexpression of ACE2 receptor. Additionally, such screens have yet to identify the protease TMPRSS2, known to be important for viral...

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發表在:Res Sq
Main Authors: Rebendenne, Antoine, Roy, Priyanka, Bonaventure, Boris, Chaves, Valadão Ana Luiza, Desmarets, Lowiese, Rouillé, Yves, Tauziet, Marine, Arnaud-Arnould, Mary, Giovannini, Donatella, Lee, Yenarae, DeWeirdt, Peter, Hegde, Mudra, Garcia de, Gracia Francisco, McKellar, Joe, Wencker, Mélanie, Dubuisson, Jean, Belouzard, Sandrine, Moncorgé, Olivier, Doench, John G., Goujon, Caroline
格式: Artigo
語言:Inglês
出版: American Journal Experts 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168385/
https://ncbi.nlm.nih.gov/pubmed/34075371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21203/rs.3.rs-555275/v1
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