Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs

Several genome-wide CRISPR knockout screens have been conducted to identify host factors regulating SARS-CoV-2 replication, but the models used have often relied on overexpression of ACE2 receptor. Additionally, such screens have yet to identify the protease TMPRSS2, known to be important for viral...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Res Sq
المؤلفون الرئيسيون: Rebendenne, Antoine, Roy, Priyanka, Bonaventure, Boris, Chaves, Valadão Ana Luiza, Desmarets, Lowiese, Rouillé, Yves, Tauziet, Marine, Arnaud-Arnould, Mary, Giovannini, Donatella, Lee, Yenarae, DeWeirdt, Peter, Hegde, Mudra, Garcia de, Gracia Francisco, McKellar, Joe, Wencker, Mélanie, Dubuisson, Jean, Belouzard, Sandrine, Moncorgé, Olivier, Doench, John G., Goujon, Caroline
التنسيق: Artigo
اللغة:Inglês
منشور في: American Journal Experts 2021
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168385/
https://ncbi.nlm.nih.gov/pubmed/34075371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21203/rs.3.rs-555275/v1
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