ATRT-09. IDENTIFICATION OF POTENTIAL GENETIC DRIVERS OF METHOTREXATE (MTX) RESISTANCE IN ATYPICAL TERATOID RHABDOID TUMOURS (ATRT) THROUGH A GENOME-WIDE RNAI SCREEN

ATRT of the CNS constitute a group of rare and aggressive early childhood tumors with poor prognosis. While there are differing chemotherapeutic regimens for ATRT, high-dose MTX is a crucial component of many therapeutic protocols. Currently, the biological mechanisms contributing to the generation...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Kannappan, Sunand, Gupa, Mehul, Kang, SungMyung, Tran, Andy Son, Thakur, Satbir Singh, Jain, Mohit, Narendran, Aru
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Atypical Teratoid Rhabdoid Tumors
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168191/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.008
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