EPEN-01. C11ORF95-RELA DICTATES ONCOGENIC TRANSCRIPTIONAL PROGRAMS TO DRIVE AGGRESSIVE SUPRATENTORIAL EPENDYMOMA

Over 60% of supratentorial (ST) ependymomas harbor a gene fusion between C11orf95, an uncharacterized gene, and RELA (also known as p65), a main component of the NF-ĸB family of transcription factors. While its sufficiency to drive tumor has been established, the mechanism of tumorigenesis remains e...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Arabzade, Amir, Zhao, Yanhua, Varadharajan, Srinidhi, Chen, Hsiao-Chi, Bertrand, Kelsey, Deneen, Benjamin, Mack, Stephen
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2021
Teme:
Ependymoma
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168166/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.051
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