EPCT-14. GD2 CAR T-CELLS MEDIATE CLINICAL ACTIVITY AND MANAGEABLE TOXICITY IN CHILDREN AND YOUNG ADULTS WITH H3K27M-MUTATED DIPG AND SPINAL CORD DMG

BACKGROUND: We previously discovered high expression of the disialoganglioside GD2 on H3K27M+ gliomas and demonstrated preclinical efficacy of intravenous (IV) GD2-targeted chimeric antigen receptor (CAR) T-cells in preclinical models of H3K27M-mutated diffuse intrinsic pontine glioma (DIPG) and dif...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Neuro Oncol
Главные авторы: Majzner, Robbie, Ramakrishna, Sneha, Mochizuki, Aaron, Patel, Shabnum, Chinnasamy, Harshini, Yeom, Kristen, Schultz, Liora, Richards, Rebecca, Campen, Cynthia, Reschke, Agnes, Mahdi, Jasia, Toland, Angus Martin Shaw, Baggott, Christina, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Landrum, Kayla, Erickson, Courtney, Rasmussen, Lindsay, Barsan, Valentin, Tamaresis, John, Marcy, Anne, Kunicki, Michael, Fujimoto, Michelle, Ehlinger, Zach, Kurra, Sreevidya, Cornell, Timothy, Partap, Sonia, Fisher, Paul, Grant, Gerald, Vogel, Hannes, Sahaf, Bita, Davis, Kara, Feldman, Steven, Mackall, Crystal, Monje, Michelle
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2021
Предметы:
Translational/Early Phase Clinical Trials
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168142/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.200
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы