EPCT-14. GD2 CAR T-CELLS MEDIATE CLINICAL ACTIVITY AND MANAGEABLE TOXICITY IN CHILDREN AND YOUNG ADULTS WITH H3K27M-MUTATED DIPG AND SPINAL CORD DMG

BACKGROUND: We previously discovered high expression of the disialoganglioside GD2 on H3K27M+ gliomas and demonstrated preclinical efficacy of intravenous (IV) GD2-targeted chimeric antigen receptor (CAR) T-cells in preclinical models of H3K27M-mutated diffuse intrinsic pontine glioma (DIPG) and dif...

সম্পূর্ণ বিবরণ

সংরক্ষণ করুন:
গ্রন্থ-পঞ্জীর বিবরন
প্রকাশিত:Neuro Oncol
প্রধান লেখক: Majzner, Robbie, Ramakrishna, Sneha, Mochizuki, Aaron, Patel, Shabnum, Chinnasamy, Harshini, Yeom, Kristen, Schultz, Liora, Richards, Rebecca, Campen, Cynthia, Reschke, Agnes, Mahdi, Jasia, Toland, Angus Martin Shaw, Baggott, Christina, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Landrum, Kayla, Erickson, Courtney, Rasmussen, Lindsay, Barsan, Valentin, Tamaresis, John, Marcy, Anne, Kunicki, Michael, Fujimoto, Michelle, Ehlinger, Zach, Kurra, Sreevidya, Cornell, Timothy, Partap, Sonia, Fisher, Paul, Grant, Gerald, Vogel, Hannes, Sahaf, Bita, Davis, Kara, Feldman, Steven, Mackall, Crystal, Monje, Michelle
বিন্যাস: Artigo
ভাষা:Inglês
প্রকাশিত: Oxford University Press 2021
বিষয়গুলি:
Translational/Early Phase Clinical Trials
অনলাইন ব্যবহার করুন:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168142/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.200
ট্যাগগুলো: ট্যাগ যুক্ত করুন
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!

অনুরূপ উপাদানগুলি