Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor

Malaria parasite egress from host erythrocytes (RBCs) is regulated by discharge of a parasite serine protease called SUB1 into the parasitophorous vacuole (PV). There, SUB1 activates a PV‐resident cysteine protease called SERA6, enabling host RBC rupture through SERA6‐mediated degradation of the RBC...

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Bibliografiset tiedot
Julkaisussa:EMBO J
Päätekijät: Tan, Michele S Y, Koussis, Konstantinos, Withers‐Martinez, Chrislaine, Howell, Steven A, Thomas, James A, Hackett, Fiona, Knuepfer, Ellen, Shen, Min, Hall, Matthew D, Snijders, Ambrosius P, Blackman, Michael J
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2021
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167364/
https://ncbi.nlm.nih.gov/pubmed/33932049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020107226
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